D-α-Tocopherol succinate CAS# 4345-03-3

Name: D-α-Tocopherol succinate CAS# 4345-03-3
SKU: 0

Classification：Pharmaceutical Raw Materials

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product description

D-α-Tocopherol succinate CAS# 4345-03-3

Tocopherol succinate (4345-03-3) is a potent antioxidant. Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2? Tocopherol succinate induces apoptosis in human gastric cancer cells3? and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14. Induces apoptosis in neuroblastoma cells.5

D-α-Tocopherol succinate Chemical Properties

Melting point	~76 °C(lit.)
Boiling point	625.8±55.0 °C(Predicted)
density	1.002±0.06 g/cm3(Predicted)
vapor pressure	0Pa at 20℃
storage temp.	-20°C
solubility	Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol.
form	Solid
pka	4.35±0.17(Predicted)
color	White or off-white
Odor	Little or no odor
biological source	synthetic
λmax	286nm(EtOH)(lit.)
Merck	14,9495
BRN	4038233
Specific Activity	1210IU/g
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
LogP	12 at 25℃
CAS DataBase Reference	4345-03-3(CAS DataBase Reference)
EPA Substance Registry System	D-.alpha.-Tocopheryl acid succinate (4345-03-3)

Safety Information

WGK Germany	1
RTECS	EJ9984000
F	8-10-23
HS Code	2936280000
Toxicity	LD50 oral in rat: > 7gm/kg

Product Usage

A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.

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