Artemisinin#63968-64-9

Name: Artemisinin#63968-64-9
SKU: 0

Classification：Plant Extracts

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product description

Artemisinin#63968-64-9

Artemisinin is an antimalarial agent with anticancer activity. It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge. It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg. It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day).

Artemisinin Chemical Properties

Melting point	156-157 °C (lit.)
alpha	76 º (c=0.5,MeOH)
Boiling point	344.94°C (rough estimate)
density	1.0984 (rough estimate)
refractive index	75 ° (C=0.5, MeOH)
storage temp.	-20°C
solubility	Soluble to 100mM in DMSO and to 75mM in ethanol
form	White to off-white crystalline solid.
color	Needles
Optical Rotation	[α]20/D +76°, c = 0.5 in methanol
Merck	14,817
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. May absorb, and react with, carbon dioxide from the air.
InChI	InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1
InChIKey	BLUAFEHZUWYNDE-NNWCWBAJSA-N
SMILES	O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)C(=O)O4)O1
LogP	2.900

Safety Information

Safety Statements	22-24/25
WGK Germany	2
RTECS	KD4170000
HS Code	29322985
Toxicity	LD50 in mice (mg/kg): 5105 orally; 2800 i.m.; 1558 i.p. (Koch); LD50 in mice, rats (mg/kg): 4228, 5576 orally; 3840, 2571 i.m. (China Cooperative Research Group on Qinghaosu)

Product Usage

Artemisia annua, as an antimalarial drug, contains artemisinin and its derivatives, which have remarkable effects in treating malaria (including various types such as malignant malaria, interday malaria, chloroquine-resistant malaria, and cerebral malaria, covering dangerous types). It features high efficiency, rapidity, low toxicity, and no cross-resistance with chloroquine

Product Packaging