Neomycin Sulfate CAS# 1405-10-3

Name: Neomycin Sulfate CAS# 1405-10-3
SKU: 0

Classification：Agricultural Chemicals

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product description

Neomycin sulfate CAS# 1405-10-3

Neomycin sulfate is an aminoglycoside antibiotic and calcium channel protein inhibitor. Neomycin sulfate also binds to prokaryotic ribosomes inhibiting translation and is effective against gram-positive and gram-negative bacteria. Neomycin sulfate inhibits PLC (Phospholipase C) via binding to inositol phospholipids. It also inhibits phosphatidylcholine-PLD activity and induces Ca2+ mobilization and PLA2 activation in human platelets. Neomycin sulfate inhibits DNase I induced DNA degradation. It is used to prevent or treat skin infections caused by bacteria. It is not effective against fungal or viral infections.

Neomycin sulfate Chemical Properties

Melting point	>187°C (dec.)
alpha	D20 +54° (c = 2 in H2O)
bulk density	640kg/m3
refractive index	56 ° (C=10, H2O)
Fp	56℃
storage temp.	2-8°C
solubility	H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.
form	powder
color	white to slightly yellow
PH	5.0-7.5 (50g/l, H2O, 20℃)
biological source	Streptomyces sp.
Water Solubility	Soluble in water
Merck	14,6454
Stability:	Stable. Incompatible with strong oxidizing agents.
InChIKey	OIXVKQDWLFHVGR-VTSVPHRWSA-N
LogP	-3.655 (est)
CAS DataBase Reference	1405-10-3(CAS DataBase Reference)
EPA Substance Registry System	Neomycin sulfate (1405-10-3)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	42/43-22
Safety Statements	23-36/37-45-22-36-24/25
WGK Germany	3
RTECS	QP4375000
F	8
TSCA	Yes
HS Code	29419000
Toxicity	LD50 oral in mouse: > 8gm

Product Usage

Neomycin sulfate is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. NEOMYCIN SULFATE has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 μM). It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures.

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